The UMD website


Welcome:

Nestled between the sea and hills, Marseille is a surprising, seasonless and enthusiastic city. Founded 2600 years ago, the oldest city in France combines the richness of its unique heritage with a vibrant cultural life in one exceptional site.
Sometimes endearing, sometimes rebellious, it loves to seduce the visitor who is rarely indifferent to the charm of its 111 districts, its mild climate and the mysteries of its gastronomy.
As France's second largest city, Marseille recalls the values of sharing that have shaped its territory for centuries, maintaining in its name "Marseille" the memory of the ancient Greek from Asia Minor that participated in its founding.
A port city with a strong identity, it has also managed to support the changes in time to become an unavoidable capital of the Mediterranean, open to the world.­
Marseille is also the home of the UMD databases hosted at INSERM UMR_S910. These tools are dedicated to the collection of mutations in human genes associated with genetic diseases. Most of these locus specific databases are freely accessible but some can only be accessed by a password.

UMD User's Manual


Learn more about Marseille

The human genome contains about 40,000 genes and presently only 3,000 are known to be implicated in genetic diseases. In the near future, the entire sequence of the human genome (Human Genome Project) will be available and the development of new methods for point mutation detection will lead to a huge increase in the identification of genes and their mutations associated with genetic diseases as well as cancers.

The collection of these mutations will be critical for researchers and clinicians to establish genotype/phenotype correlations. Other fields such as molecular epidemiology will also be developed using these new data. Consequently, the future lies not in simple repositories of locus-specific mutations but in dynamic databases linked to various computerized tools for their analysis and that can be directly queried on-line. To meet this goal, we devised a generic software called UMD (Universal Mutation Database).

It was developed as a generic software to create locus-specific databases (LSDBs) with the 4th Dimension® package from 4D. The UMD software includes an optimized structure to assist and secure data entry and to allow the input of a wide range of clinical data. In addition various analyzing tools have been specifically designed to assist clinicians (phenotype-genotype correlations...), geneticists (distribution and frequency of mutations...) and research biologists (structural domains, molecular epidemiology...). Thanks to the flexible structure of the UMD software, it has been successfully adapted to many genes either involved in cancer (APC, BRCA1, BRCA2, TP53, RB1, MEN1, SUR1, VHL, WT1...) or in genetic diseases (FBN1, LDLR, DMD, VLCAD, MCAD, LMNA, EMD, FKRP, SGCG, SGCA, ATP7B...). This tool is freely available. To download the software please visit the download policy webpage.


Copyrights:
The UMD Software Copyright (c) 1992-2015 – Mr. Christophe Beroud. All rights reserved. You shall not duplicate or transfer the UMD Software, in whole or in part, in whatever media or manner (electronic format, handwriting process or other), including but not limited to, through copies, downloads, research systems or information storage, for any purpose, without Mr. Christophe Beroud's prior written approval. The rights to adapt, translate, arrange, correct and, more generally, modify the UMD Software are exclusively reserved, at any time and in any place, to Mr. Christophe Beroud.

The UMD Locus Specific Databases constitute the intellectual property of the inventors of each database. Any unauthorised copying, storage or distribution of this material without written permission from the inventors would lead to copyright infringement with possible ensuing litigation.

For further details, please refer to Directive 96/9/EC of the European Parliament and of the Council of 11 March 1996 on the legal protection of databases.