The UMD-VHL mutations database
Record ID: 958

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.227_229delTCTp.Phe76_Phe76delHeterozygous5- Causal

wt codonwt aamutant codonmutant aamutational eventmutation type
TTCPhedel3bInFIn frame delInF

StructureKey Residue (HCD)Pyrimidin doubletCpG
Linker 2 Yes, coding strand

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): BspW I, Fnu4H I

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
01-GR21-A12I-ProbandFemale

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
198634692
Clinical Research Group for VHL in Japan, Germline mutations in the von Hippel-Lindau disease (VHL) gene in Japanese VHL Human Molecular Genetics, 1995, 4 : 2233-2237