The UMD-VHL mutations database
Record ID: 1122

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.414A>Gp.Pro138ProHeterozygous5- Causal

wt codonwt aamutant codonmutant aamutational eventmutation type
CCAProCCGProA->GTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Tail NoNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0 - 18 (Polymorphism)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
01-GI18-E12S-ProbandFemale

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
10929891534
IDENTIFICATION OF A NEW VHL EXON AND COMPLEX SPLICING ALTERATION IN FAMILIAL ERYTHROCYTOSIS OR VON HIPPEL LINDAU DISEASE LENGLET AND AL,2018