| New Amino Acid | Number of residues (positions) | Number of mutations |
|---|
| Cys | 17 (62, 122, 240, 485, 545, 627, 650, 954, 974, 1530, 1820, 1832, 1915, 2108, 2150, 2576, 2680) | 152 |
| Deletion | 16 (122, 525, 565, 1119, 1469, 1523, 1691, 1692, 1692, 1692, 1771, 1906, 1997, 2051, 2242, 2422) | 18 |
| Gln | 6 (529, 2057, 2414, 2554, 2694, 2726) | 9 |
| Gly | 4 (439, 516, 636, 1530) | 10 |
| His | 6 (240, 954, 976, 1170, 1530, 1632) | 22 |
| Ile | 1 (636) | 1 |
| Insertion | 4 (658, 1428, 1541, 2355) | 4 |
| Lys | 1 (1969) | 1 |
| Pro | 4 (545, 1137, 1790, 1832) | 6 |
| Ser | 1 (1915) | 1 |
| Stop | 22 (165, 215, 364, 429, 516, 529, 565, 861, 1125, 1523, 1539, 1541, 1596, 1644, 1790, 1997, 2057, 2220, 2394, 2414, 2694, 2776) | 179 |
| Trp | 4 (2282, 2335, 2554, 2726) | 21 |